Duke enters Final Four as a worthy favorite, but how can you ignore Houston's experience, defense and grit? Beware the upset!

What you need to know about the Houston Cougars' Final Four semifinal against Duke, a rematch of last year's Sweet 16.

After two exciting weekends of NCAA Tournament action, the 2025 Final Four field is set. The bracket started with 68 teams earlier this month, and the field has since shrunk to a mere quartet ahead of what should be a historic Final Four next weekend.

Who's going to win the gathering of Goliaths that'll arrive in San Antonio later this week? That's what we're hear to tell you, and Duke is a good place to start

If Duke wins it all, one bettor could turn a $5, five-leg parlay into a huge payday, complementing the $20k they've already made. Patrick Everson has the scoop.

It's why they're now considered one of the country's most successful, consistent teams annually — and why they're one of four teams still playing Saturday in March Madness. “That’s what we do,” Midwest Region Most Outstanding Player Emanuel Sharp said after Sunday's 69-50 win over Tennessee.

Madness odds for Houston Cougars vs Duke Blue Devils Final Four NCAA Tournament game, including point spread, moneyline, over/under for betting.

Final Four picks, predictions, odds explain why Duke Blue Devils will beat Houston Cougars in NCAA Tournament March Madness game Saturday, April 5.

No. 1 seed Duke, led by National Player of the Year candidate Cooper Flagg, will square off against No. 1 seed Houston, while No. 1 seed Florida faces No. 1 Auburn in the national semifinals. Florida will make its first appearance in the Final Four since 2014.