Alendronate sodium is a bisphosphonate used to treat Paget disease of bone (PDB). The approved dosage of 40 mg/day for 6 months is generally well tolerated, but esophageal irritation can occur if the ...

This drug had not previously been considered by the PBAC for this indication. Osteoporosis must be confirmed by the finding of low bone mass of at least 2 standard deviations below the gender specific ...

If alendronate 35 mg weekly is prescribed to maintain bone density, clinicians should also recommend supplemental calcium intake, such as 1,000–1,500 mg per day, and maintain serum vitamin 25OHD ...

Fosamax (alendronate) is now available in a 70-mg formulation. Are there any differences in alendronate formulation between the 10-mg tablet and the new 70-mg tablet? My question is prompted by a ...

In the United States, 2 amino bisphosphonates -- alendronate and risedronate-- are currently approved for the prevention and treatment of osteoporosis. The primary clinical trials that provided ...

Romosozumab is a monoclonal antibody that binds to and inhibits sclerostin, increases bone formation, and decreases bone resorption. We enrolled 4093 postmenopausal women with osteoporosis and a ...