Sepsis, a critical condition characterized by life-threatening organ dysfunction, arises from a dysregulated host response to infection. The resultant immunosuppression constitutes the primary ...

Researchers at Brigham and Women's Hospital (BWH) have discovered a new cellular and molecular pathway that regulates CD4+ T cell response--a finding that may lead to new ways to treat diseases that ...

T cell maturation is dependent on the intrathymic proliferation, survival and differentiation of precursor cells. These processes are regulated to a large extent by signals received through the pre-T ...

A study, published in the journal MedComm and led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the dedicator of cytokinesis 8 (DOCK8) gene in the ...

CD4+ T cells, or helper T cells, are one type of lymphocyte that helps coordinate the immune response against infection and disease. They interact and activate other cells in the immune system. The ...

Idiopathic CD4 lymphocytopenia (ICL) is a clinical syndrome that is defined by CD4 lymphopenia of less than 300 cells per cubic millimeter in the absence of any primary or acquired cause of ...

What Is the CD4:CD8 Ratio Test Used For? CD4 and CD8 are two types of white blood cells in your blood. White blood cells help your body fight infections. If you have HIV infection, your doctor may use ...