Oncotarget published "NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells" which reported that peripheral T-cell lymphoma is characterized by ...

Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids (Cell Reports 2023) Published:12/26/2023 12/26/2023 • By Yao Rong , Alicia M. Darnell , Kiera M. Sapp , ...

P21 is a cell cycle inhibitor that promotes both CDK/cyclin inhibition as well as cell cycle arrest during the G1/S phase. Skip to content. Menu. Medical Home Life Sciences Home.

On February 19, 2023, Mikhail V. Blagosklonny published a new review in Aging's Volume 15, Issue 4, entitled, “Cellular senescence: when growth stimulation meets cell cycle arrest.” ...

Using cell-based assays, patient-derived xenografts (PDX), and transgenic mouse models, we show that INX-315 (i) promotes retinoblastoma protein hypophosphorylation and therapy-induced senescence (TIS ...

The growth and division of a cell is orchestrated into a highly controlled and ordered process called the cell cycle. The cell cycle contains 4 stages; Gap 1 (G1) phase, synthesis (S) phase, gap 2 ...

p53-mediated cell cycle arrest results demonstrate potential of ALRN-6924 to prevent chemotherapy-induced neutropenia, thrombocytopenia, and anemia, as well as chemotherapy-induced alopecia (hair ...

The cell cycle also serves to protect the cell from DNA damage. Thus, cell cycle arrest, in fact, represents a survival mechanism that provides the tumor cell the opportunity to repair its own damaged ...

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic and epigenetic events cause universal overactivity of the cell cycle cdks ...