By applying a second inhibitor (flavopiridol) that blocks the activity of Cdk–cyclin ... the cell cycle, so crucial to the long term viability of cells, is a systems-level property of the ...
The exact molecular functions of Polo-like kinase 1 (PLK1) in mitotic prophase are not fully understood. This study shows that PLK1 inhibition delays activation of CDK1-cyclin B and halts cells for ...
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