Here, we identified a circuit, locus coeruleus descending noradrenergic neurons projecting to the spinal dorsal horn (LC →SDH -NA neurons), that is activated by acute exposure to restraint stress and ...
The antidepressant's analgesic effects are believed to stem from its inhibition of serotonin and norepinephrine reuptake, which among other things, regulates descending pain pathways. However, the ...
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