This is thought to result in analgesic effects through the neurotransmitters' action on the descending pain pathways. [42] TCAs act on pain at dosages much lower (25 mg daily for amitriptyline ...

According to published results, a novel opioid-free pathway may provide noninferior pain management compared with an opioid-containing pathway during the perioperative period in patients undergoing ...

We study the hypothesis according to which plasticity in pain signaling and modulating pathways contributes to long-lasting ... Moreover, we study plasticity in descending pain regulation, such as ...