Augusta University has patented NSAID derivatives acting as prostaglandin G/H synthase 1 (PTGS1; COX-1) and/or COX-2 inhibitors potentially useful for the treatment of inflammation and pain.

For many years, nonsteroidal inflammatory drugs (NSAIDs) have been the first choice of doctors to control the joint swelling and inflammation associated with rheumatoid arthritis (RA). Almost everyone ...

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...

London, UK - Although they have come in for a tremendous amount of criticism over the past year, the selective COX-2 inhibitors may turn out to be a better bet overall than the older nonselective ...

COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found. "The results of the ...

Anti-inflammatory drugs have long served as a cornerstone in the treatment of conditions marked by inflammation, pain, and fever. At the heart of many of these therapeutic agents lies the inhibition ...

Cyclooxygenase (COX) is the rate-limiting enzyme of prostanoid biosynthesis and ubiquitously found in most cells including microvascular endothelium and vascular smooth muscle (VSM). COX has two major ...

NEW YORK, July 18 (Praxis Press) A new class of nonsteroidal anti-inflammatory drugs selectively inhibits cyclooxygenase (COX)-2 and may produce fewer adverse effects than nonselective inhibitors.

Analgesics called Cox-2 inhibitors, which U.S. health officials restricted Thursday, can not only damage the heart and blood vessels but may also suppress the immune system, researchers said. A study ...

AAT-076 was tested in the preclinical setting for its analgesic potential in COX-1 and COX-2 assays, as well as in in vivo rat models of air pouch inflammation, adjuvant-induced arthritis and ...

VANDERBILT: A surprising new scientific finding may hold answers to better treatment or prevention of ovarian cancer and will certainly alter the course of cancer research. Research being published ...