Klotho Therapeutics Inc. has synthesized new histone deacetylase 8 (HDAC8) inhibitors reported to be useful for the treatment of acute kidney injury and chronic kidney disease.

Histone deacetylases (HDACs) are enzymes, which catalyze the removal of acetyl moiety from acetyl-lysine within the histone proteins and promote gene repression and silencing resulting in several ...

Metastasized melanoma cells in the brain mark the end stages of the cancer’s progression. The process by which the cells get to the brain is a complex one but a new study has identified one of the ...

Following an injury, such as a traumatic crush injury, the peripheral nervous system is itself often able to effectively regenerate. This capacity of regeneration is mainly attributable to the Schwann ...

Researchers have been working to better understand what drives melanoma brain metastasis. They now report on the identification of a cell signaling pathway that regulates the metastatic spread of ...

Melanoma is the deadliest form of skin cancer because of its ability to quickly grow and spread throughout the body. More than half of those with advanced melanoma will see the disease spread to the ...