3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the key regulatory enzyme of the isoprenoid pathway, was found to be predominantly microsomal in Ochromonas malhamensis, a chrysophytic alga.

Please provide your email address to receive an email when new articles are posted on . Genetic inhibition of HMG-CoA reductase, a state that mimics long-term statin use, was associated with greater ...

Purpose: Clinical trials evaluating the effectiveness of therapy with hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors for reducing elevated C-reactive protein (CRP) levels and ...

Concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) for newly diagnosed glioblastoma multiforme (GBM). Conclusive results of a randomized phase III trial by the EORTC Brain & RT Groups ...

Advanced glycation endproducts (AGEs)-induced vascular smooth muscle cell (VSMCs) proliferation and formation of reactive oxygen species (ROS) are emerging as one of the important mechanisms of ...

BEER-SHEVA, Israel, March 21, 2023 – Statins are the most commonly used medication in lowering blood cholesterol, prescribed to tens of millions in the Western world. Statins act through inhibition of ...

There are many potential factors that may affect statin use in the clinical setting. We are not aware of any studies in the published literature examining predictors of statin use in kidney ...

Immune-mediated necrotizing myopathy with antibodies against the enzyme targeted by statins, HMG-CoA reductase, was found in a woman with no history of using a statin or taking red yeast rice ...

Women who take statins “long term” may be less likely to develop ovarian cancer, research suggests. The cholesterol-lowering drugs have proved controversial over the years, with many arguing they are ...

Hypertriglyceridemia contributes to the atherosclerotic process and maintaining normal serum triglyceride levels have some support to lower the risk of heart attack, stroke and cardiovascular death.