Researchers looked at whether or not it was necessary to stock dantrolene, a drug used to treat malignant hyperthermia, at facilities using succinylcholine alone instead of volatile anesthetics, ...
A team of researchers has found that mutations in the calcium channel protein RyR1 that confer susceptibility to malignant hyperthermia make the protein hypersensitive to heat, which triggers ...
Malignant hyperthermia is a potential side effect or complication that may arise in patients who have received general anesthesia. This adverse event typically occurs during surgery and other invasive ...
Malignant hyperthermia (MH) is a life‐threatening pharmacogenetic disorder of skeletal muscle characterised by a hypermetabolic response to certain anaesthetic agents. Research in this field has ...
A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and ...
LINCOLNSHIRE, Ill.--(BUSINESS WIRE)--Nexus Pharmaceuticals announced the launch of Succinylcholine Chloride Injection, USP in 200mg/10mL Multiple-Dose Vials. It is an AP-rated generic to QUELICIN™ ¥. ...
Schematic representation of the mechanism leading to prolonged bleeding time due to RYR1 mutations. In normal conditions (left panel), early vasospasm occurring immediately after injury reduces ...
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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
Beyond its implications for malignant hyperthermia, this research provides a valuable model to study other RyR1-related disorders, such as muscular dystrophy, cancer-associated muscle weakness, and ...
A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and ...
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