Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 22 (May 31, 2016), pp. 6242-6247 (6 pages) Cysteinyl leukotrienes (cysLTs), leukotriene C₄ (LTC₄), LTD₄, ...
Inflammation and its timely resolution represent a vital physiologic response to infection, injury, and “sterile provocation” by endogenous stimuli. There is a growing appreciation that the initiation ...
Allergies occur when the immune system treats a harmless foreign protein as an invader. The immune system mounts a full-scale response to the protein. This response involves releasing inflammatory ...
Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n–6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves arterial inflammation, we ...
Macrophage polarization is critical to inflammation and resolution of inflammation. We previously showed that high-mobility group box 1 (HMGB1) can engage receptor for advanced glycation end product ...
The incidence of asthma has dramatically increased over recent years and although currently available treatments are generally effective, patient compliance is currently poor, especially with respect ...
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