The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in eukaryotic transcription regulation, and its formation is the major rate-limiting step in transcriptional activation.

The senescence response to oncogenes is believed to be a barrier to oncogenic transformation in premalignant lesions, and describing the mechanisms by which tumor cells evade this response is ...

Did you know that the DNA in any cell of the human body—or any organism for that matter—contains the genetic information required to develop every possible type of cell within that organism? Yet cell ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (RNAPII), governs the expression of all protein-coding and most non-coding ...

Sequence-specific, DNA-binding TFs are the major regulators of cell identity and cell physiology. As examples, expression of select TFs can revert differentiated cells back to a pluripotent state and ...

Researchers at Umeå University, Sweden, have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide. The discovery may be ...

Small (left) and large (right) condensates of the Mediator complex inside nuclei of a pancreatic beta cell-derived cell line. Salk researchers discovered that GLP-1s interact with the multi-protein ...

A new study advances existing knowledge about transcription and gene expression. This multi-institution team of researchers made interesting discoveries about the role of the Mediator protein complex ...

Did you know that the DNA in any cell of the human body - or any organism for that matter - contains the genetic information required to develop every possible type of cell within that organism? Yet ...