A major factor in coronavirus disease 2019 (COVID-19)-associated mortality is the development of coagulation abnormalities that may result in thromboembolism. Human platelets have been found by ...

When cancer cells and platelets mix, the risk of metastasis and cancer-related deep vein thrombosis (DVT) and pulmonary embolism (PE) increases, but a small, proof-of-concept study suggests that the ...

Researchers have identified serine threonine kinase 10 as a key regulator of platelet function, haemostasis and ...

A small study testing the pharmacodynamic effects of several antiplatelet agents suggests that tirofiban (Aggrastat; Medicure), a glycoprotein IIb/IIIa inhibitor, may provide “more potent and ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

The 5' nucleotidase protein apyrase is found in the saliva of all blood feeding arthropods (and an analogue in Vampire bats and leeches). Apyrases are enzymes that degrade ATP and ADP to AMP and ...

Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients. H 2 S modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling ...

A new study created a score to identify patients with platelet hyperreactivity and risk of related, future cardiovascular disease. Platelets are circulating cell fragments known to clump up and form ...

Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels. Cardiologists have long known that platelets can become "hyperreactive" to cause ...