The pathogens that cause tropical diseases rely on an essential protein that is absent from all other organism. This ...

Cavities at protein-protein interaction interfaces are often considered "undruggable" because their shallow or large geometries hinder the stable binding by small molecules. A study published ...

When cancer-driving proteins resist various treatments, Northwestern University scientists have uncovered a new solution. Don't fight them—throw them in the cellular trash. In a new study published in ...

HYDRACs are a class of proteomimetic polymers designed to mark harmful proteins, like MYC and KRAS, for destruction rather than merely block their activity.

Many biological functions are regulated by the switching on and off of mechanisms triggered by the matching of a keyhole ...

Researchers say study results provide a clear rationale for developing therapies that target LCN2 in lung cancer patients.

Designing drugs is a bit like playing with Polly Pocket. The vintage toy is a plastic clam shell that contains a multi-bedroom house, a skating rink, a disco dance floor, and other fun scenarios. Kids ...