Excessive phosphate loading within the proximal tubular lumen has been proposed as a key mechanism driving progression of chronic kidney disease (CKD) through calcium phosphate microcrystallopathy.

Magnesium is an important cofactor for numerous enzymes. All ATPase reactions require Mg 2+ –ATP, including those involved in RNA and DNA biologic functions. It opposes calcium actions and acts as a ...

Reduction of renal tubular cell polynucleotide phosphorylase (PNPT1) expression has been linked to renal tubular atrophy in chronic kidney disease, according to a new study. The research, published in ...

Renal tubular acidosis may signal subclinical kidney involvement in patients with mutations in the TTR gene, according to new research. Some 18.3% of the symptomatic and asymptomatic patients with TTR ...

Chronic kidney disease (CKD) is a public health challenge that affects more than 800 million people worldwide. 1 CKD can be caused by a variety of disease processes. Many causes are difficult to ...