GEN

Lifespan in Mice Shortens with Increase in Nutrient Signaling to mTOR

As the aging population increases, the race to unpack the molecular understanding of aging heats up. The rapamycin (mTOR) complex 1 (mTORC1) is known to be a key component of multiple functions of the ...
EurekAlert!

Phytic acid-based nanomedicine against mTOR for metabolic dysfunction-associated steatohepatitis therapy

CePA exerts a liver-targeted mTOR repressive function, alleviating MASH progression and fat accumulation in high-fat diet-fed mice. Metabolic dysfunction-associated steatohepatitis (MASH) is one of ...
BioWorld

Items Tagged with 'mTOR inhibitors'

Galderma Holding SA has identified metabolites of CD-14547 acting as mammalian target of rapamycin (mTOR; FRAP1) inhibitors. As such, they are reported to be useful for the treatment of acne, atopic ...
BioWorld

Littdd Medicines discovers new mTORC1 and mTORC2 inhibitors

Littdd Medicines Ltd. has described mTOR complex 1 (mTORC1) and/or mTOR complex 2 (mTORC2) inhibitors reported to be useful for the treatment of cancer, idiopathic pulmonary fibrosis, transplant ...