Prisco's Week 16 NFL picks: Seahawks top Rams on 'TNF,' Packers edge Bears, Jaguars upset Broncos
This will be the second start for Philip Rivers for the Colts after he almost won at Seattle last week. The 49ers are 10-4 and pushing for a playoff spot. They blew out Tennessee last week, but the defense wasn't great. It won't matter as the 49ers will limit Rivers and Brock Purdy will play well. The 49ers keep on winning.