One group showed that p53 controlled the progression of the cell cycle, but it wasn’t clear how. 24 Guillermina Lozano entered the p53 field as a postdoctoral fellow in Levine’s lab in 1985 and ...

Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs) that, among other activities, causes cell-cycle arrest, and BAX, which promotes apoptotic cell death.

the mechanisms by which p53 mediates cell-cycle arrest or apoptosis still remain unclear. There must be some way to specify which target genes of p53 are to be selected. The different serine ...

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review ...

TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell ...

A new research paper was published in Oncotarget , Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells." ...