Gut

Neutrophil extracellular traps induced by tumour-derived NGAL reprogram CAF subtypes via ITGA5 to promote tumour progression in pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) is largely refractory to immune checkpoint blockade, owing to its ...
Gut

DR1-DR2 enrichment in HBeAg-negative chronic hepatitis B: integration hotspot or survivor signature?

We read with great interest the recent study by Lau et al , who reported distinct intrahepatic hepatitis B virus (HBV) ...
Gut

Multimodal C9-66 CAR-T cell immunotherapy improves outcome in preclinical models of pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers due to its aggressive biology and ...
GutOpinion

Conclusions in search of a confirmatory analysis: the evidence does not yet justify routine proton pump inhibitors after endoscopic variceal ligation

The trial by Yadav and colleagues concludes that proton pump inhibitors (PPIs) should be continued routinely after endoscopic ...
gut.bmj

Visceral pain—peripheral sensitisation

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
gut.bmj

PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury

Objectives Autoimmune hepatitis (AIH) is a severe necroinflammatory liver disease associated with significant mortality. Although loss of hepatocytes is generally recognised as a key trigger of liver ...
gut.bmj

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

Objective Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where ...
gut.bmj

Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review

4 Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia Correspondence to Dr Hashem B El-Serag, Section of Gastroenterology and ...
gut.bmj

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome

8 Women's and Children's Hospital, South Australia, Australia Objective The purpose of this study was the clinical and pathological characterisation of a new autosomal dominant gastric polyposis ...
gut.bmj

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

Clinic for Internal Medicine I, University Hospital of Ulm, Ulm, Germany Background: CD147 (basigin, EMMPRIN) is a multifunctional, highly conserved glycoprotein enriched in pancreatic ductal ...
gut.bmj

Asymptomatic primary biliary cirrhosis: clinical features, prognosis, and symptom progression in a large population based cohort

Background: Many patients with primary biliary cirrhosis (PBC) are asymptomatic at the time of diagnosis. However, because most studies of asymptomatic PBC have been small and from tertiary centres, ...
gut.bmj

Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis

Correspondence to: Dr M Prince, Centre for Liver Research, 4th Floor William Leech Building, Newcastle University Medical School, Framlington Place, Newcastle NE2 4HH, UK; Martin.prince{at}ncl.ac.uk ...