Background Subcutaneous (SC) administration is the preferred parenteral opioid route in palliative care, while intravenous infusion may allow faster titration. Comparative evidence remains limited.

The Terminally Ill Adults (End of Life) Bill is currently under debate within the UK Parliament. If passed, the bill will affect individuals living in England and Wales, providing a legal framework ...

Context Methadone is a useful option in the treatment of cancer pain. Despite its advantages, methadone use is complicated due to high interindividual variability in pharmacokinetics. Various rotation ...

Home-based oncology palliative care is racing against time. In Florence, Italy—a city with approximately 364 073 inhabitants in 2024, with 990 527 in its metropolitan area1—a resolute team of four ...

Hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels control neuronal firing thresholds. Together with sodium channels, they accumulate at sites of nerve injury, creating ectopic foci of ...

Aim (s) and method (s) The aim of this review is to identify patient and family views on DNACPR decisions and their experiences after having had DNACPR discussions. Methods: A literature search of ...

Objectives Supportive and palliative care include non-oncology settings where patients suffer from pain and quality of life-related concerns. Integrative medicine plays important roles in supportive ...

Aim To assess the mortality rate and the use of palliative sedation (PS) in an advanced long-standing acute palliative care unit (APCU) Methods The charts of patients who died and eventually received ...

Orthostatic hypotension is a relatively common medical diagnosis and can be debilitating for the patients it affects. There is a range of treatment options, though only one medication is licensed in ...

Background Three trajectories of physical decline have been identified towards the end of life: (i) a short period of evident decline typically experienced by patients with cancer; (ii) long term ...