Deregulating CDK activity by changes in phosphorylation, cyclin availability ... identification of an additional level of control. The performance of the cell-cycle machinery is monitored by ...

By applying a second inhibitor (flavopiridol) that blocks the activity of Cdk–cyclin ... the cell cycle, so crucial to the long term viability of cells, is a systems-level property of the ...

Cyclin B3, on the other hand, plays an important role in meiosis, another type of cell division. It is responsible for ensuring that meiotic division takes place correctly and that a healthy egg ...

If the kinase moves freely within the cell, it primarily phosphorylates amino acids in optimal environments. However, if cyclin B docks onto substrates via its pocket, then the kinase 'piggybacks ...