This is thought to result in analgesic effects through the neurotransmitters' action on the descending pain pathways. [42] TCAs act on pain at dosages much lower (25 mg daily for amitriptyline ...

We study the hypothesis according to which plasticity in pain signaling and modulating pathways contributes to long-lasting ... Moreover, we study plasticity in descending pain regulation, such as ...

According to published results, a novel opioid-free pathway may provide noninferior pain management compared with an opioid-containing pathway during the perioperative period in patients undergoing ...