Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing ...
RNA has emerged as one of the most promising molecules in modern medicine, enabling advances from mRNA vaccines and gene ...
Inherited retinal degenerations are a diverse group of genetic disorders that result in progressive vision loss. Advances in ...
The search for bioactive molecules is an intense and continuous area of research. In this context, nucleosides, nucleotides and nucleic acids play a special role e.g. these classes of molecules are ...
Ever since humans began building, they’ve been building up. Throughout the millennia, our constructions have reached higher and higher into the sky, spurred by various motivations: religion, democracy ...
The eukaryotic genome is organized in the form of a highly compact nucleoprotein complex, the chromatin. Nucleosome, the basic unit of chromatin, consists of ~147 bp of DNA wrapped 1.65 times around a ...
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