Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. [1] Onset of lung problems is typically between 20 and 50 years of …

Alpha-1 antitrypsin deficiency (sometimes just called “Alpha-1”) is an inherited genetic disorder that causes low levels of a protein (AAT) that protects your lungs.

Dec 6, 2025 · Learn about the symptoms and risk factors of alpha-1-antitrypsin deficiency, a condition passed down in families, that can affect the lungs, liver or both.

Nov 25, 2025 · Learn about the causes, symptoms, and treatment for alpha-1 antitrypsin (AAT) deficiency, along with questions for your doctor and tips for living with it.

Alpha-1 antitrypsin deficiency (AATD) is an inherited disease that causes an increased risk of having chronic obstructive pulmonary disease (COPD), liver disease, skin problems …

Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary …

Alpha-1 is the #1 known genetic risk factor for COPD 1 Alpha-1 may be a contributing cause in approximately 3 in 10 cases of COPD in the United States 2 Alpha 1 -antitrypsin (AAT) …

Aug 19, 2024 · Alpha-1 antitrypsin (AAT) deficiency is a condition in which the body does not make enough of AAT, a protein that protects the lungs and liver from damage. The condition …

Mar 12, 2025 · In alpha-1 antitrypsin deficiency, the body’s normal production of the AAT protein is impaired, resulting in the destruction of sensitive lung tissue. Learn more about what causes …

Dec 3, 2025 · Alpha 1 antitrypsin deficiency (AATD) is a rare, autosomal co-dominant genetic disorder caused by mutations in the SERPINA1 gene. Both alleles contribute to circulating …