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  1. Below is the full 189,819-lettered word for 'titin': Methionylthreonylthreonylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleuc ...

  2. Titin - Wikipedia

    Titin is the third most abundant protein in muscle (after myosin and actin), and an adult human contains approximately 0.5 kg of titin. [13] With its length of ~27,000 to ~35,000 amino acids …

  3. TTN gene: MedlinePlus Genetics

    The TTN gene provides instructions for making a very large protein called titin. Learn about this gene and related health conditions.

  4. The multiple roles of titin in muscle contraction and force …

    Titin is a filamentous protein spanning the half-sarcomere, with spring-like properties in the I-band region. Various structural, signaling, and mechanical functions have been associated with titin, …

  5. PDB-101: Molecule of the Month: Titin

    Titin is the largest protein chain in your body, with more than 34,000 amino acids. This titanic protein acts like a big rubber band in our muscles. It is attached at one end to the Z-disk …

  6. Titin: roles in cardiac function and diseases - Frontiers

    Apr 10, 2024 · With a molecular weight of ∼3–4 MDa (in humans), titin is the largest protein expressed in mammals, extending from the Z-disk to the M-band where the N- and C-termini …

  7. Entry - *188840 - TITIN; TTN - OMIM - (OMIM.ORG)

    The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.

  8. Titin: The Body’s Largest Protein and Its Role in Muscle

    Jul 21, 2025 · An adult human body contains about 0.5 kg of titin, making it the third most abundant protein in muscle tissue, following only actin and myosin. A single molecule of titin is …

  9. Discovery of Titin and Its Role in Heart Function and Disease

    Jan 2, 2025 · This review examines the giant elastic protein titin and its critical roles in heart function, both in health and disease, as discovered since its identification nearly 50 years ago.

  10. Titin - American Chemical Society

    May 2, 2022 · Titin, also called connectin, is the largest known protein. It is found in the striated muscle tissue of humans and other vertebrates; homologous proteins exist in invertebrate …